Figure 3 | Cell Death & Disease

Figure 3

From: Tumor suppressor PDCD4 modulates miR-184-mediated direct suppression of C-MYC and BCL2 blocking cell growth and survival in nasopharyngeal carcinoma

Figure 3

PDCD4 controls the expression of cell cycle and transcription factor C-JUN in NPC via PI3K/AKT/JNK pathway. (a) Overexpressed PDCD4 suppressed the expression of pPI3K, pAKT and JNK in clone 1 and 2 cells compared with scramble cells. (b) Reduced PDCD4 elevated the expression of pPI3K, pAKT and JNK in shPDCD4 SUNE1 and HONE1 cells compared with their respective controls. (c) Restored PDCD4 inhibited the expression of C-MYC, CCND1, pRB (Ser780), E2F1 and C-JUN in clone 1 and 2 cells compared with scramble cells. (d) Downregulated PDCD4 expression stimulated the C-MYC, CCND1, pRB (Ser780), E2F1 and C-JUN expression in shPDCD4 SUNE1 and HONE1 cells compared with their respective controls

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