Figure 3
Metabolic fluxes as a function of the proliferation rate. (a–i) Estimated metabolic fluxes of reactions in the SOG pathway are shown as a function of the proliferation rates of cell lines. Each point/error bar represents a cell line in the NCI60 panel. The point represents the median over the range of model kinetic parameters explored, and the error bars represent the 90% confidence intervals. The dashed lines are linear fits. Panels (b and e) report exchange fluxes as measured in.11 These fluxes are fixed in the personalized models and, therefore, they do not display error bars due to variations in the model kinetic parameters
