Figure 4

MT2A overexpression modulates cell response to cytotoxic agents. (a) SaOS2 parental and MT2A-overexpressing cells were incubated with or without cisplatin or transplatin for 48 h. Cell viability was evaluated using the MTT test. (b) U2OS parental and MT2A-overexpressing cells were incubated with or without cisplatin or transplatin for 48 h. Cell viability was evaluated using the MTT test. (c) SaOS2 parental and MT2A-overexpressing cells were incubated with or without doxorubicin or vincristine. Cell viability was evaluated using the MTT test. (d) U2OS parental and MT2A-overexpressing cells were incubated with or without doxorubicin or vincristine. Cell viability was evaluated using the MTT test. Results are expressed as mean±S.D. and as arbitrary units relative to corresponding untreated cells. *P<0.05 versus untreated cells; #P<0.05 versus parental cells