Table 1 Expression profiles of p63 isoforms in various tissues
From: Role of the p63-FoxN1 regulatory axis in thymic epithelial cell homeostasis during aging
Tissues | TAp63 (role or implication) | ΔNp63 (role or implication) | Ref. |
|---|---|---|---|
Skin (during embryogenesis) | Early developmental stages (undifferentiated epithelium) (expressed first to initiate stratification of the epithelium and prevent terminal differentiation) | After initiation of stratification (allows keratinocytes to respond to signals that are required for the maturation of the epidermis and commitment to terminal differentiation) | |
Epithelial tumors (during tumorigenesis and in response to therapy) | Benign, smaller and less aggressive tumors (mediates suppression of tumorigenesis through the induction of senescence) | Malignant and aggressive tumors (mediates tumorigenesis, probably associated with the existence of a large number of tumor stem cells) | |
Thymus | Aged thymus (expression increases in correlation to thymic epithelial cell senescence, due to blockade of TEC differentiation) | Fetal and young thymus (associated with activated thymic epithelial progenitor cells) | Candi et al.9 and this report |
