Figure 2 | Cell Death & Disease

Figure 2

From: Expression of integrin alpha 10 is transcriptionally activated by pRb in mouse osteoblasts and is downregulated in multiple solid tumors

Figure 2

Schematic of the integrin α10 promoter. (a) Schematic shows the eight 5′-nested deletion constructs characterized (Δ590, Δ463, Δ397, Δ275, Δ232, Δ163, Δ108, Δ55), the five site-directed mutants of the Δ590 construct (Δ590-YY1, Δ590-HBP1(1), Δ590-PAX6, Δ590-HBP1(2), Δ590-SP1) with their four base pair substitutions, the putative transcription factor binding sites (underlined), and the primers used for cloning (highlighted in gray). All constructs begin at the base pair by which they are named (upstream relative to the start of the site of transcription) and end at +60

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