Table 1 Oncomine (http://www.oncomine.org, Compendia Bioscience, Ann Arbor, MI, USA) was used for analysis of integrin expression in seven common solid tumor types

From: Expression of integrin alpha 10 is transcriptionally activated by pRb in mouse osteoblasts and is downregulated in multiple solid tumors

Database

Integrin α 7

Integrin α 8

Integrin α 10

Integrin β 4

 

Fold Change

P-value

Fold Change

P-value

Fold Change

P-value

Fold Change

P-value

Dyrskjot Bladder 3

−1.587

−1.63E-05

−1.475

2.25E-04

−1.604

3.99E-07

2.313

1.82E-05

Haqq Melanoma

NC

2.68E-01

−1.504

3.00E-03

−3.471

2.04E-04

N/A

N/A

Hou Lung

−1.734

1.64E-14

−5.742

1.91E-15

−1.828

2.88E-18

3.591

8.92E-10

Jones Renal

−1.523

2.45E-05

−3.993

7.00E-17

−1.499

5.91E-10

2.500

2.00E-03

Kaiser Colon

NC

9.40E-02

−1.494

1.00E-03

−1.222

6.09E-06

2.852

5.81E-05

Landi Lung

−1.239

1.01E-07

−2.375

4.58E-17

−1.357

9.02E-14

1.588

3.36E-07

Richardson Breast

−5.362

3.41E-06

NC

1.70E-02

−3.491

2.00E-06

−2.735*

1.86E-08

  1. The fold change value is determined by comparing the means of the two classes in an analysis on a log2 scale and then converting that difference to a linear scale (http://www.oncomine.org). NC, no significant difference in expression between normal and tumor tissue. N/A, this study did not have a probe for the gene of interest. Only one significant change occurred in the opposite direction of the other six data sets and is denoted with an asterisk
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