Figure 4 | Cell Death & Disease

Figure 4

From: miR-16 and miR-26a target checkpoint kinases Wee1 and Chk1 in response to p53 activation by genotoxic stress

Figure 4

p53 differentially affects expression of primary and mature miR-16-2 and miR-26a. Effect of p53 activation by doxorubicin on the transcription of primary miR-16-1, miR-16-2, and miR-26a-1 gene in p53+ and p53− U2-OS cells was measured by Q-RT-PCR. Levels of pri-miRs expression were normalized to the signal of U6 RNA. (b) Shown are the expression levels of mature (transcription-independent) miR-16 and miR-26a, relative to U6

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