Figure 1 | Cell Death & Disease

Figure 1

From: Wentilactone A as a novel potential antitumor agent induces apoptosis and G2/M arrest of human lung carcinoma cells, and is mediated by HRas-GTP accumulation to excessively activate the Ras/Raf/ERK/p53-p21 pathway

Figure 1

The effects of Wentilactone A (WA) on cell growth inhibition and colony formation. (a) Chemical structure of Wentilactone A. (b) HUVEC and human lung carcinoma cells (NCI-H460 and NCI-H446 cells) were treated with 0, 2.5, 5, 10, 20, 40, 80 μM of WA for 24 and 48 h, respectively. Cell viability was detected by MTT assay. (c) Effect of WA on the number of colony-forming cells as evaluated by clonogenic assay. Colonies were stained with trypan blue. Values are means±S.D. from three independent experiments

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