Figure 1 | Cell Death & Disease

Figure 1

From: STAT1-mediated Bim expression promotes the apoptosis of retinal pericytes under high glucose conditions

Figure 1

Diabetes induces apoptosis of PCs in retinal vasculature. (a) Retinal frozen sections were prepared from wild-type and Akita/+ mice. Double immunofluorescence staining was performed for PDGFR-β and TUNEL. Arrowheads indicate TUNEL- and PDGFR-β-positive cells in the superficial layer of the retina. Bar indicates 20 μm. (b) Quantification of TUNEL and PDGFR-β-positive cells is shown. Data are presented as mean±S.E.M. (n=7 for wild-type and n=8 for Akita/+ mice; *P<0.05 compared with wild-type mice). (c) The effects of high glucose on apoptosis of retinal PCs. Retinal PCs cultured under high glucose conditions exhibited a significantly higher rate of apoptosis. NG: normal glucose condition; HG: high glucose condition. Similar results were observed under fluctuation conditions (n≥3; *P≤0.05 (NG versus HG or fluctuation))

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