Figure 6 | Cell Death & Disease

Figure 6

From: STAT1-mediated Bim expression promotes the apoptosis of retinal pericytes under high glucose conditions

Figure 6

Bim expression is essential for high glucose (HG)-mediated apoptosis and ROS production of PCs. (a) Bim−/− PCs were resistant to HG-induced apoptosis. Wild-type (WT) and Bim−/− PCs were incubated under normal glucose (NG) or HG conditions for 5 days. HG did not increase the rate of apoptosis in Bim−/− PCs (n≥3; *P≤0.05 (LG versus HG)). (b) Bim−/− PCs generated less ROS under HG conditions (n≥100; *P≤0.05 (NG versus HG)). (c) Migration of Bim−/− PCs was not affected under HG conditions, whereas the migration of WT PCs was attenuated under HG condition (n≥3; *P≤0.05 (NG versus HG))

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