Figure 3 | Cell Death & Disease

Figure 3

From: Macrophages commit postnatal endothelium-derived progenitors to angiogenesis and restrict endothelial to mesenchymal transition during muscle regeneration

Figure 3

MP depletion impairs neo-angiogenesis in regenerating skeletal muscles. (a) Skeletal muscles of sham liposome- and Cll-treated mice were acutely injured by injection of CTX, and retrieved immediately before and 5, 10 and 15 days after damage. Panels show representative images of TA (left panels) and triceps (TR) (right panels) muscle cross-sections immunostained for CD31. Magnification × 20. Scale bar: 50 μm. (b and c) Density and area of blood vessels were measured in healthy and CTX-treated TA and TR muscles of sham- and Cll-treated mice. The capillary vessel density (b) and the mean capillary area (c) were evaluated by digital image analysis of randomly selected muscle sections immunostained for CD31. The capillary vessel density was expressed as number of capillaries per square millimeter. The data are expressed as means±S.E.M. (n=3). Statistically significant differences are indicated (sham versus Cll *P<0.05)

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