Figure 6 | Cell Death & Disease

Figure 6

From: Macrophages commit postnatal endothelium-derived progenitors to angiogenesis and restrict endothelial to mesenchymal transition during muscle regeneration

Figure 6

MP depletion leads to incoming fibrosis. (a) Sirius red, Masson’s trichromic and Red O staining of representative TA sections from Cll-untreated/treated Cdh5-CreERT2; R26R-NZG mice 21 days after CTX injection, showing the accumulation of excess fibrous connective tissue and of adipocytes in Cll-treated muscle. Magnification × 10 and × 20. Scale bar: 50 μm. (b) Fibrosis at 15, 18 and 21 days after ctx, in sham- and Cll-treated triceps, was quantified by digital image analysis of randomly selected muscle sections stained for Sirius red. Fibrosis was expressed as area per μm2. The data are expressed as means±S.E.M. (n=3). Statistically significant differences are indicated (sham versus Cll *P<0.05; **P<0.01; ***P<0.005)

Back to article page