Figure 1

TBI mouse model. (a) Unilateral sensorimotor cortex contusion by TBI (34 days after injury). (b–i) Immunohistochemistry for anti-GFP and Nissl, which were injected with PRV-EGFP to the impaired forelimb, in the cortex of the sham (b and c), TBI (d and e), TBI+reaching (f and g), and TBI+rotarod groups (h and i) at day 39. (c, e, g and i) Magnified views of EGFP-positive layer V neurons in the contralateral (sham) and ipsilateral (TBI, TBI+reaching, and TBI+rotarod groups) cortex to the impaired side, respectively. Scale bars: 200 μm. (j) Percentage of lesion volume in the injured hemisphere