Figure 3
From: HDAC inhibitors induce tumor-cell-selective pro-apoptotic transcriptional responses
Regulation of gene expression in BJ and BJ LTSTERas by vorinostat. (a) The number of probe sets that were significantly altered in BJ and BJ LTSTERas cells in response to treatment with vorinostat. Probe sets that were induced and repressed by at least 1.5-fold at any of the 4, 12 and 24 h time points relative to time 0 h are shown. (b) Genes that responded differently to vorinostat treatment in matched normal and transformed cells (contrast genes) were analyzed using the IPA tool. The associations of various molecular and cellular functions with contrast genes are plotted in decreasing order of statistical significance, according to −log2 (P-value). P-values were adjusted for multiple testing using the method of Benjamini and Hochberg. The orange line indicates the threshold for statistical significance (P<0.05)
