Figure 4
From: HDAC inhibitors induce tumor-cell-selective pro-apoptotic transcriptional responses
Ingenuity pathways analysis. Interaction map of the death receptor pathway was created using the ingenuity pathways analysis tool (a) BJ and (b) BJ LTSTERas fibroblasts. (c, d) An interaction map of the BCL-2 family of apoptotic regulators was created using the ingenuity pathways analysis tool, and overlaid with transcriptional responses to vorinostat in (c) BJ and (d) BJ LTSTERas fibroblasts. For (a–d), the direction and magnitude of vorinostat-mediated expression changes following 24 h of treatment, relative to time 0 h are indicated by pseudo-coloring. Induced (red), repressed (green) and non-responding probe sets (white) are shown. Log2 expression values of the strongest responding probe sets for each vorinostat-responding pathway component are shown. Interactions between BH3-only and pro-survival proteins are based upon Biacore analyses described in reference 26. Interactions between multi-domain proteins BAX/BAK and other BCL-2 family members were based on ingenuity pathway information
