Table 1 Connectivity map for vorinostat-responding genes in treated BJ cells

From: HDAC inhibitors induce tumor-cell-selective pro-apoptotic transcriptional responses

Rank

Cmap name

Mean

n

Enrichment

P -value

Specificity

% Non-null

1

Vorinostat

0.762

12

0.977

0.00000

0.0151

100

2

Trichostatin A

0.695

182

0.922

0.00000

0.0047

96

3

Resveratrol

0.342

9

0.873

0.00000

0.0049

100

4

Valproic acid

0.238

57

0.488

0.00000

0.0000

68

5

Sirolimus

0.102

44

0.439

0.00000

0.1024

50

6

LY-294002

0.194

61

0.421

0.00000

0.0940

67

7

Scriptaid

0.747

3

0.980

0.00004

0.0000

100

8

Rifabutin

0.695

3

0.973

0.00004

0.0000

100

9

Prochlorperazine

0.209

16

0.571

0.00004

0.0631

81

10

Trifluoperazine

0.204

16

0.549

0.00006

0.1442

68

11

Thioridazine

0.196

20

0.509

0.00008

0.2329

80

12

Syrosingopine

0.327

4

0.900

0.00010

0.0093

100

13

CP-690334-01

0.275

8

0.685

0.00036

0.0121

75

14

Loperamide

0.235

6

0.756

0.00050

0.0152

100

15

Parbendazole

−0.365

4

−0.874

0.00054

0.0000

50

16

Tanespimycin

0.115

62

0.248

0.00064

0.5285

54

17

Mefloquine

0.291

5

0.795

0.00084

0.0588

100

18

Fluphenazine

0.166

18

0.441

0.00089

0.1814

66

19

Securinine

−0.582

4

−0.852

0.00092

0.0127

75

20

MS-275

0.609

2

0.974

0.00111

0.0433

100