Table 1 Connectivity map for vorinostat-responding genes in treated BJ cells
From: HDAC inhibitors induce tumor-cell-selective pro-apoptotic transcriptional responses
Rank | Cmap name | Mean | n | Enrichment | P -value | Specificity | % Non-null |
---|---|---|---|---|---|---|---|
1 | Vorinostat | 0.762 | 12 | 0.977 | 0.00000 | 0.0151 | 100 |
2 | Trichostatin A | 0.695 | 182 | 0.922 | 0.00000 | 0.0047 | 96 |
3 | Resveratrol | 0.342 | 9 | 0.873 | 0.00000 | 0.0049 | 100 |
4 | Valproic acid | 0.238 | 57 | 0.488 | 0.00000 | 0.0000 | 68 |
5 | Sirolimus | 0.102 | 44 | 0.439 | 0.00000 | 0.1024 | 50 |
6 | LY-294002 | 0.194 | 61 | 0.421 | 0.00000 | 0.0940 | 67 |
7 | Scriptaid | 0.747 | 3 | 0.980 | 0.00004 | 0.0000 | 100 |
8 | Rifabutin | 0.695 | 3 | 0.973 | 0.00004 | 0.0000 | 100 |
9 | Prochlorperazine | 0.209 | 16 | 0.571 | 0.00004 | 0.0631 | 81 |
10 | Trifluoperazine | 0.204 | 16 | 0.549 | 0.00006 | 0.1442 | 68 |
11 | Thioridazine | 0.196 | 20 | 0.509 | 0.00008 | 0.2329 | 80 |
12 | Syrosingopine | 0.327 | 4 | 0.900 | 0.00010 | 0.0093 | 100 |
13 | CP-690334-01 | 0.275 | 8 | 0.685 | 0.00036 | 0.0121 | 75 |
14 | Loperamide | 0.235 | 6 | 0.756 | 0.00050 | 0.0152 | 100 |
15 | Parbendazole | −0.365 | 4 | −0.874 | 0.00054 | 0.0000 | 50 |
16 | Tanespimycin | 0.115 | 62 | 0.248 | 0.00064 | 0.5285 | 54 |
17 | Mefloquine | 0.291 | 5 | 0.795 | 0.00084 | 0.0588 | 100 |
18 | Fluphenazine | 0.166 | 18 | 0.441 | 0.00089 | 0.1814 | 66 |
19 | Securinine | −0.582 | 4 | −0.852 | 0.00092 | 0.0127 | 75 |
20 | MS-275 | 0.609 | 2 | 0.974 | 0.00111 | 0.0433 | 100 |