Table 2 Connectivity map for vorinostat-responding genes in treated BJ LTSTERas cells
From: HDAC inhibitors induce tumor-cell-selective pro-apoptotic transcriptional responses
Rank | Cmap name | Mean | n | Enrichment | P -value | Specificity | % Non-null |
---|---|---|---|---|---|---|---|
1 | Vorinostat | 0.816 | 12 | 0.978 | 0.00000 | 0.0151 | 100 |
2 | Trichostatin A | 0.703 | 182 | 0.932 | 0.00000 | 0.0000 | 96 |
3 | Resveratrol | 0.243 | 9 | 0.861 | 0.00000 | 0.0098 | 100 |
4 | CP-690334-01 | 0.358 | 8 | 0.802 | 0.00000 | 0.0121 | 87 |
5 | 15-Delta prostaglandin J2 | 0.202 | 15 | 0.696 | 0.00000 | 0.0447 | 86 |
6 | LY-294002 | 0.168 | 61 | 0.577 | 0.00000 | 0.0134 | 73 |
7 | Valproic acid | 0.171 | 57 | 0.482 | 0.00000 | 0.0000 | 61 |
8 | Scriptaid | 0.777 | 3 | 0.978 | 0.00004 | 0.0000 | 100 |
9 | Rifabutin | 0.650 | 3 | 0.973 | 0.00010 | 0.0000 | 100 |
10 | 5707885 | 0.282 | 4 | 0.899 | 0.00030 | 0.0052 | 100 |
11 | Thiostrepton | 0.247 | 4 | 0.880 | 0.00034 | 0.0392 | 100 |
12 | Phenoxybenzamine | 0.261 | 4 | 0.876 | 0.00046 | 0.2030 | 100 |
13 | Ciclopirox | 0.196 | 4 | 0.864 | 0.00101 | 0.0338 | 100 |
14 | Isotretinoin | 0.197 | 4 | 0.842 | 0.00050 | 0.0000 | 100 |
15 | Bacitracin | −0.410 | 3 | −0.913 | 0.00112 | 0.0121 | 100 |
16 | Sertaconazole | −0.249 | 4 | −0.834 | 0.00137 | 0.0000 | 75 |
17 | Mycophenolic acid | 0.252 | 3 | 0.910 | 0.00154 | 0.0452 | 100 |
18 | Syrosingopine | 0.260 | 4 | 0.822 | 0.00173 | 0.0326 | 100 |
19 | MG-262 | 0.314 | 3 | 0.902 | 0.00184 | 0.1676 | 100 |
20 | Fenoprofen | −0.187 | 6 | −0.683 | 0.00266 | 0.0255 | 50 |