Figure 5 | Cell Death & Disease

Figure 5

From: Grafting of neural stem and progenitor cells to the hippocampus of young, irradiated mice causes gliosis and disrupts the granule cell layer

Figure 5

Effects of age and interval between IR and grafting on phenotype. Cell phenotype was evaluated 5 weeks after grafting. When grafting 1 day after IR, neuronal differentiation (BrdU+/NeuN+ cells) was lower, whereas differentiation into astrocytes (BrdU+/S100β+ cells) was higher in the irradiated versus non-irradiated brains. The phenotype of grafted cells was not significantly different between irradiated and control brains when transplantation was performed 1 or 6 weeks post-IR. In non-irradiated, control brains, lower age at the time of grafting favored neuronal differentiation and higher age favored astroglial differentiation. The ratio of unidentified cells was three times higher in the older recipient brains, but not different between irradiated and non-irradiated brains. Data represent the mean±S.E.M. **P<0.01 when comparing irradiated with non-irradiated brains. #P<0.05, ##P<0.01 and ###P<0.001 when comparing 1 week (P21) or 6 weeks (P56) brains with 1 day (P15) brains

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