Figure 1
From: ATP/P2X7 axis modulates myeloid-derived suppressor cell functions in neuroblastoma microenvironment

ATP detection in NB tumor microenvironment by pmeLUC probe. Immunocompetent A/J mice (n=4) were i.v. injected with pmeLUC-NXS2 cells (2 × 105 cells/mouse). Panel a shows the animals imaged by bioluminescence 12, 19 and 26 days after tumor cell inoculum. Panel b shows a representative animal subjected to post-mortem macroscopic analysis. A light-emitting metastasis localized in the abdominal cavity is indicated by red arrow. This is a representative experiment out of three performed