Figure 4 | Cell Death & Disease

Figure 4

From: ATP/P2X7 axis modulates myeloid-derived suppressor cell functions in neuroblastoma microenvironment

Figure 4

P2X7R expression in M-MDSCs and G-MDSCs in NB-bearing mice. Panel a shows the expression of murine P2X7R mRNA in TF and NB tumor-bearing (NB) M-MDSCs and G-MDSCs. RT-PCR was performed as described in Materials and Methods. GA3PDH amplification was used as positive control. Panel b shows P2X7R expression and localization in M-MDSCs and G-MDSCs by fluorescence microscopy. White arrows indicate P2X7R localization on the plasma membrane. Original magnification × 40, inset panels × 100. Panel c shows basal and BzATP-stimulated CCL2 release by NB M-MDSCs

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