Figure 4 | Cell Death & Disease

Figure 4

From: Inhibition of human mitochondrial peptide deformylase causes apoptosis in c-myc-overexpressing hematopoietic cancers

Figure 4

Actinonin-mediated apoptosis begins in the mitochondria. (a) Actinonin (15 μM) causes mitochondrial membrane depolarization in Ramos cells as measured by JC1 dye beginning by 2 h. (b) Inhibition of mitochondrial protein translation begins at 4 h as shown by incorporation of 35S (top) and densitometric measurement (bottom) of the same (c) Caspase-3/7 activation begins at 6 h

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