Figure 3 | Cell Death & Disease

Figure 3

From: Arginine vasopressin neuronal loss results from autophagy-associated cell death in a mouse model for familial neurohypophysial diabetes insipidus

Figure 3

Electron microscopic analysis in AVP neurons of 3-month-old FNDI mice. AVP neurons of the SON in 3-month-old FNDI mice with water access ad libitum (a–d) and of those subjected to WD for 4 weeks (e–h). Higher magnification images of boxed areas in (a, c, e and g) are shown in (b, d, f and h), respectively. The arrowheads in (d) indicate irregular-shaped aggregates confined to some compartments of the ER, which seem to communicate with intact ER lumen, and those in (h) indicate phagophores engulfing the ER, which contains scattered aggregates. Scale bars, 2 μm (a, e and g), 1 μm (c)

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