Figure 6 | Cell Death & Disease

Figure 6

From: Arginine vasopressin neuronal loss results from autophagy-associated cell death in a mouse model for familial neurohypophysial diabetes insipidus

Figure 6

AVP neuronal loss in FNDI mice subjected to WD. (a and b) Immunohistochemistry for NPII in the SON of 5-month-old FNDI mice with water access ad libitum (ad lib) and of those subjected to WD for 12 weeks (WD12). (c) The number of NPII-expressing cells in the SON counted with immunohistochemistry. (d and e) In situ hybridization for AVP hnRNA in the SON of 5-month-old FNDI mice in ad lib and WD12 groups. (f) The number of AVP hnRNA-expressing cells in the SON counted with in situ hybridization. (g and h) Higher magnification images of boxed areas in (d and e), respectively. (i) The numbers of AVP hnRNA grains per cell are shown. Results are expressed as means±S.E. *P<0.05, ***P<0.001 compared with ad lib group. n=5–8 animals per group. Scale bars, 100 μm (a and b), 50 μm (d and e), 20 μm (g and h)

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