Table 2 Intravenous and oral pharmacokinetic parameters of MPT0G009 and SAHA in rats

From: Preclinical anti-arthritic study and pharmacokinetic properties of a potent histone deacetylase inhibitor MPT0G009

Parameters

MPT0G009

SAHA 30

 

i.v. 2 mg/kg

p.o. 20 mg/kg

i.v. 2 mg/kg

p.o.5 mg/kg

CL (l/h/kg)

5.12

—

8.04

—

Vd (l/kg)

25.21

—

3.92

—

T1/2 (h)

6.74

9.53

0.64

1.13

AUC(0-inf) (ng h/ml)

665

1265

278

49.40

Tmax (h)

—

3.43

—

0.17

Cmax (ng/ml)

—

221

—

83.90

F (%)

—

13.0

—

6.9

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