Figure 3
From: Sirtuin-3 (SIRT3), a therapeutic target with oncogenic and tumor-suppressive function in cancer
SIRT3 in cancer cell. SIRT3 can limit ROS levels in cancer cell, thereby leading to the destabilization and subsequent degradation of HIF-1α. Moreover, SIRT3 overexpression may prevent intracellular acidification, Bax activation and MPT induction
