Figure 7 | Cell Death & Disease

Figure 7

From: Selective 14-3-3γ induction quenches p-β-catenin Ser37/Bax-enhanced cell death in cerebral cortical neurons during ischemia

Figure 7

14-3-3γ suppresses OGD/ischemia-induced Bax in cortical neurons in vitro and in vivo. (a) Representative fluorescent micrographs showing the expression of Bax in cultured neurons upon 4 or 6 h of OGD. (b) Representative micrographs of IHC showing the expression of Bax in cortical neurons of the Contra and Ipsi of rats subjected to 1 h of pMCAo. (c) Representative micrographs of double-fluorescent immunostaining showing the segregation of 14-3-3γ and Bax expression in the Ipsi of rats subjected to 6 h of pMCAo. (d) Representative Western blot results and statistical analysis showing the effects of 14-3-3γ knockdown on Bax and cleaved caspase-3 levels in cultured cortical neurons upon 4 h of OGD. **P<0.01 versus N-con (n=3)

Back to article page