Figure 2

OPN deficiency aggravated the liver inflammation induced by I–R. The gene expression of iNOS (a), TNFα (b), IL6 (c) and IFNγ (d) was evaluated for control and ischemic-reperfused lobes (ischemia for 45 min and then 4 h of reperfusion) from Wt (Wt Ctr; Wt I–R) (n=8–10), Opn^−/− (Opn^−/− Ctr; Opn^−/− I–R) (n=5) and SHAM mice (n=4–6). The mRNA levels were normalized to RPLP0 mRNA levels and expressed as fold stimulation±S.E.M. versus SHAM or Wt Ctr. Data were statistically analyzed using the Mann–Whitney test. ^¤versus SHAM, *versus Wt Ctr, ^$versus Wt I–R and ^#versus Opn^−/− Ctr. P<0.05