Table 1 EC50 calculated after 72 h of treatment with UCN-01

From: Combined PDK1 and CHK1 inhibition is required to kill glioblastoma stem-like cells in vitro and in vivo

GSC no.

EC50 (μ M)

Sensitivity

T98G

0.003

High

12

0.043

High

15

0.090

High

5

0.094

High

14

0.184

High

13

0.221

High

10

0.242

High

11

0.367

Medium

18

0.414

Medium

7

0.548

Medium

4

0.581

Medium

6

0.628

Medium

8

0.805

Medium

9

0.949

Medium

1

1.436

Low

17

1.938

Low

U87MG

2.711

Low

16

3.416

Low

3

4269.117

Low

20

79056.358

Low

2

227826.165

Low

19

341092.047

Low

  1. Sensitivity range: high <250 nM; 250 nM < medium <1 μM; low >1 μM.
  2. GSC lines are ordered by their sensitivity to UCN-01
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