Figure 3
From: Sec-containing TrxR1 is essential for self-sufficiency of cells by control of glucose-derived H2O2
Txnrd1 knockout cells are more sensitive to GSH depletion. The extent of cell lysis as indicator of cell death was estimated after 48 h of incubation with or without 25 nM selenite and/or 250 μM BSO, by determining total LDH activity released to the extracellular medium (n=3, ±S.E.M.). Significant differences between the untreated cells without addition of selenite and the other samples within each cell line are indicated (*P<0.05; n.s., not significant, P>0.05)
