Figure 8 | Cell Death & Disease

Figure 8

From: Suppression of tumor angiogenesis by targeting the protein neddylation pathway

Figure 8

Working model. Inhibition of neddylation pathway with MLN4924 suppresses angiogenesis by inducing cullin deneddylation, CRL inactivation and accumulation of CRL substrates that impairs migration, proliferation and survival of vascular endothelial cells. Genetic inactivation of CRL via ROC1/RBX1 siRNA silencing recapitulates the antiangiogenic effect of MLN4924. N8, Nedd8; SR, substrate receptor; DDR, DNA damage response

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