Figure 1

AD subnetwork analysis. (a) General landscape of interactions between genes/proteins belonging to the AD pathway (map05010; KEGG Pathway; http://www.genome.jp/kegg/pathway.html). The in silico network model was developed by using the STRING 9.05 database resource search tool, under a confidence score of 0.600 and using ‘Databases’ and ‘Experiments’ as input options. (b) Focused microarray analyses of AD-related genes in the cerebellum of autistic patients versus healthy controls over the in silico model. The z axis for representing the relative gene expression was constructed by using the ViaComplex software