Figure 4 | Cell Death & Disease

Figure 4

From: Arginase 2 deficiency reduces hyperoxia-mediated retinal neurodegeneration through the regulation of polyamine metabolism

Figure 4

Analysis of polyamines in OIR retina. (a) Simplified flow chart showing the polyamine interconversion pathway. SMO, spermine oxidase; APAO, acetyl polyamine oxidase; SSAT, spermine spermidine acetyl transferase. Modified from Narayanan et al.44 (b) Using mass spectrometry, levels of spermine, spermidine, putrescine, N-acetyl spermine and N-acetyl spermidine were analyzed in the retinal samples collected on P9 (2 days of hyperoxia) and their relative levels are normalized to internal standards used. Changes in polyamine metabolism are observed in WT OIR retina. Data presented as mean±S.E.M. *WT RA versus WT OIR (P<0.05), §A2−/− OIR versus WT OIR (P<0.05), N varies from 10 to 12

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