Figure 6 | Cell Death & Disease

Figure 6

From: Arginase 2 deficiency reduces hyperoxia-mediated retinal neurodegeneration through the regulation of polyamine metabolism

Figure 6

Signaling mechanisms of hyperoxia-mediated neuronal death in OIR retina. (a) Western blot analysis showing the phosphorylation levels of JNK/SAPK P54 and JNK/SAPK P46. (b) Quantification of phosphorylation changes in JNK/SAPK P54 and JNK/SAPK 46. (c) Western blot analysis showing the expression of FASL, BID, cleaved BID and cytochrome c in WT OIR retina as compared with A2−/− OIR retina and RA controls. (d) Quantification of changes in these signaling molecules in WT RA, WT OIR, A2−/− RA and A2−/− OIR retinas. Data are presented as mean±S.D. *WT RA versus WT OIR (P<0.01), §A2−/− OIR versus WT OIR (P<0.01), N varies from four to six

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