Figure 3 | Cell Death & Disease

Figure 3

From: The B-RafV600E inhibitor dabrafenib selectively inhibits RIP3 and alleviates acetaminophen-induced liver injury

Figure 3

Effects of dabrafenib on the Ser358 phosphorylation of MLKL and the interaction between RIP3, RIP1 or MLKL in HT29 cells. (a) Dabrafenib (10 μM) inhibited the Ser358 phosphorylation of MLKL induced by TSZ at the indicated times. (b) Effects of dabrafenib on the interaction between RIP3, RIP1 or MLKL in the cells exposed to the indicated combinations for 6 h. con, control; D, dabrafenib (10 μM); N, necrostatin-1 (10 μM); S, Smac mimetic (100 nM); Z, z-VAD-fmk (20 μM); T, TNF-α (20 ng/ml). The data were representative of three independent experiments

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