Figure 6
Dabrafenib alleviates acetaminophen-induced hepatotoxicity in mice. Mice were treated with 300 mg/kg acetaminophen (i.p.), with or without pretreatment with 300 mg/kg or 100 mg/kg dabrafenib (p.o.). Plasma alanine aminotransferase (ALT) (a) and aspartate aminotransferase (AST) (b) were determined. Data were expressed as mean±S.D.; n=10. In a, *P=0.015 and **P=0.0007; and in b, *P=0.03; **P=0.002. (c) The histological changes in mouse liver tissues shown by hematoxylin and eosin (H&E) staining. (d) TUNEL staining for nuclear DNA fragmentation in mouse liver cells. The typical images were captured under an optical microscope at × 20 (c) or × 40 (d) magnification
