Figure 1 | Cell Death & Disease

Figure 1

From: DYRK1A promotes dopaminergic neuron survival in the developing brain and in a mouse model of Parkinson’s disease

Figure 1

Expression of the Dyrk1a protein in the mouse ventral mesencephalon during development. (a) Schematic sagittal view of the mouse embryonic neural tube (E11.5 to E14.5) indicating the site of DA neurogenesis in the mesencephalon (yellow area) and the position occupied by DA progenitors (blue), immature DA neurons (TH− cell in yellow) and mature DA neurons (TH+ cells in red) in a transverse section at the level indicated by the black rectangle. (b and c) Confocal images showing co-localization of Dyrk1a (D1a in green) and TH (red) in the ventral mesencephalon of wild-type E12.5 embryos (b) and P0 mice (c). HIND, hindbrain; IZ, intermediate zone; MES, mesencephalon; MZ, mantle zone; TEL, telencephalon; VZ, ventricular zone. Bar=50 μm

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