Figure 4 | Cell Death & Disease

Figure 4

From: DYRK1A promotes dopaminergic neuron survival in the developing brain and in a mouse model of Parkinson’s disease

Figure 4

Numbers of apoptotic cells in the ventral mesencephalon of newborn Dyrk1a mutant mice. (a) Confocal images from brain sections of a P0 wild-type (WT) mouse showing TH expression in mesencephalic neurons that contain active Casp9 (A-Casp9) or active Casp3 (A-Casp3), and total numbers of A-Casp9+ cells (b and c) and A-Casp3+ cells (d and e) in the ventral mesencephalon (VTA+SN) of P0 Dyrk1a+/+ (D1a+/+) and Dyrk1a+/− (D1a+/−) mice (b and d), and of wild-type (WT) and mBACtgDyrk1a (BACD1a) mice (c and e). Histogram values are the mean±S.E.M. *P≤0.05; **P≤0.01; ***P≤0.001 (n=4 in (b and d); n=3 in (c and e))

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