Figure 3 | Cell Death & Disease

Figure 3

From: Retinal pigment epithelial cells undergoing mitotic catastrophe are vulnerable to autophagy inhibition

Figure 3

RPE-MC cells are vulnerable to autophagy inhibition. The values are expressed as the mean±S.D. (a) Viability assay showing that autophagy inhibition augments the reduction of viability caused by rotenone treatment. **P<0.01. (b) Autophagy flux assay indicating that autophagy inhibitors blocked autophagy flux. (c) Western blotting analysis demonstrating that autophagy inhibitors induced the accumulation of LC3-II without augmenting apoptosis. (d) Giemsa staining showing that autophagy inhibitors did not reverse the rotenone-induced multinucleation. The numbers indicate the percentage of cells with multiple nuclei. The values are expressed as the mean±S.D. See Figure 2 for other definitions

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