Table 2 Summary of vasoactive agonist-induced contractile responses
Vasoactive agonists | ATMC-derived VSM-like cells | Mouse vena cava SMCs | Rat aortic SMCs |
|---|---|---|---|
dH2O+50 nM ET1 | ++ (7) | ++ (1) | +++ (1) |
1 μM BQ123+50 nM ET1 | −/+ (2) | ND | ND |
1 μM BQ788+50 nM ET1 | + (2) | ND | ND |
1 μM BQ123+ 1 μM BQ788+50 nM ET1 | −(2) | ND | ND |
60 mM KCl | + (5) | ++ (1) | ++ (1) |
10 μM Vasopressin | +↔++ (7) | ++ (1) | +++ (1) |
10 μM Oxytocin | −/+↔++ (4) | + (1) | ++ (1) |
100 μM Norepinephrine | −/+↔++ (5) | + (1) | + (1) |
100 μM Serotonin | −/+↔++ (4) | + (1) | + (1) |
10 μM Angiotensin II | −/+↔++ (5) | ++ (1) | +++ (1) |
1 mM Carbachol | −↔+ (5) | + (1) | ++ (1) |
