Table 2 Summary of the long-term effects of prenatal ketamine exposure on morphological, molecular, functional and behavioral parameters in female and male Gad67-GFP mice in vivo
Gad67-GFP mice | Density of Gad67-GFP neurons | Number of primary dendrites | Density of dendritic spines | Cortical GABA levels | Expression of GAT1 and GAT3 | Expression of Gad |
|---|---|---|---|---|---|---|
Females | ↘ | ↘ | ↘ | ≈ | ≈ | ↘ |
Males | ↘ | ↘ | ↘ | ↗ | ↗ | ↘ |
Gad67-GFP mice | Expression of GluN1 | Cortical glutamate levels | Expression of PSD95 | Mobilization of calcium levels after glutamate stimulation | Spontaneous locomotor activity |
|---|---|---|---|---|---|
Females | ↘ | ≈ | ↗ | ↗ | ↗ |
Males | ↘ | ≈ | ↘ | ≈ | ≈ |
