Figure 1

Cytochrome c biointeractome in human and plant cells under PCD conditions. The overall function and cellular localization of the novel protein targets of cytochrome c reported by Martínez-Fábregas et al.^{5, 6} are those described in the literature. Human and plant cytochrome c targets are in red and green, respectively; other proteins are in yellow. Continuous lines are drawn according to the previously known roles of such proteins in activation and inhibition paths, whereas dashed lines stand for their interactions with cytochrome c as reported in Martínez-Fábregas et al.^{5, 6} Red and green lines denote interactions in human and plant cells, respectively; blue lines denote interactions involving pairs of analogous proteins in humans and plants (in squares). Yellow lines indicate translocation of proteins between endoplasmic reticulum and cytoplasm, as previously reported. Abbreviations: ALDOA, aldolase A; ANP32B, acidic nuclear phosphoprotein 32 member B; Apaf-1, apoptosis protease-activating factor-1; ASK1, apoptosis signal-regulating kinase 1; Bcl-2/Bcl-xL, B-cell lymphoma 2 and extra large; BiP1/BiP2, luminal-binding protein 1 and 2; Cc, cytochrome c; eIF2α, eukaryotic translation initiation factor 2 alpha; eIF2γ, eukaryotic translation initiation factor 2 gamma; GAPC1, glyceraldehyde-3-phosphate dehydrogenase C subunit 1; GLY2, hydroxyacylglutathione hydrolase; hnRNP C1/C2, heterogeneous nuclear ribonucleoprotein C1/C2; HSPA5, heat shock 70-kDa protein 5; MCM6, minichromosome maintenance complex 6; NCL, nucleolin; NF-κB, nuclear factor kappa-light-chain-enhancer of activated B cells; NRP1, nucleosome assembly protein 1-related protein 1; PKB, protein kinase B (or Akt); PKC, protein kinase C; RD21, cysteine proteinase RD21; SET, SET nuclear oncogene; Sm/D1, small nuclear ribonucleoprotein D1; STRAP, Ser/Thr kinase receptor associated protein; TCL, transcriptional coactivator-like (or AtALY1); TGF-β, transforming growth factor beta; YWHAE, 14-3-3 epsilon