Figure 5
From: Improving the therapeutic potential of endostatin by fusing it with the BAX BH3 death domain
Effect of ES and ES-BAX on tumor growth. BALB/c mice (n=5 per group) received s.c. injections with 2 × 105 Renca cells. When tumors reached 100 mm3, mice received daily s.c. injections of buffer or 15 μg of either ES or ES-BAX/g of mice. On day 11 after beginning of the treatment of the first set of mice, the animals were euthanized, and the tumors were removed, weighed, and photographed. This procedure was repeated until the treatment of all of the animals was concluded. (a) Kinetics of tumor growth during the 10-day treatment. (b) Photographs from representative tumors withdrawn on day 11 after the beginning of the treatment. (c) Average tumor weight on day 11. Error bars: mean±S.E.M. Statistical significance was determined using a Student’s t-test (two-tailed), **P<0.005; *** P<0.0001. This assay was performed twice
