Figure 6

The effect of PARP1 inhibitors (PJ-34 and DPQ) on SE-induced astroglial responses in the hippocampus and the PC in vivo. (a) In the CA1 region, both PARP1 inhibitors inhibit SE-induced reactive gliosis to the extent of non-SE level at 3 days after SE. In the CA3 region, both PARP1 inhibitors induce astroglial death in the stratum lucidum following SE. In the DG region, both PARP1 inhibitors aggravate astroglial loss in the molecular layer of the dentate gyrus following SE. In the PC, PARP1 inhibitors do not affect SE-induced astroglial death at 3 days after SE. Bar=50 μm. (b) The effect of PARP1 inhibitors (DPQ and PJ-34) on GS expression is similar to those on GFAP expression in the hippocampus and the PC in vivo. Bar=50 μm. (c) Quantification of the number of astrocytes following SE (means±S.D., n=5, respectively). *P<0.05 versus non-SE animals (one-way ANOVA test)