Figure 8 | Cell Death & Disease

Figure 8

From: PARP1 activation/expression modulates regional-specific neuronal and glial responses to seizure in a hemodynamic-independent manner

Figure 8

The effect of PARP1 inhibitors (PJ-34 and DPQ) on PILO-induced astroglial responses in the hippocampus and the PC ex vivo. (a) ACSF+PILO did not induce neuronal death in the CA1–3 regions and the dentate gyrus. Both PARP1 inhibitors induced astroglial loss in the stratum lucidum of the CA3 region. In the PC region, ACSF+PILO induced astroglial loss. Both PARP1 inhibitors are ineffective to astroglial death induced by ACSF+PILO. Bar=50 μm. (b) Quantification of the number of astrocytes (means±S.D., n=5, respectively). *P<0.05 versus normal ACSF (one-way ANOVA test)

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