Figure 1 | Cell Death & Disease

Figure 1

From: Amyloid-β induces NLRP1-dependent neuronal pyroptosis in models of Alzheimer’s disease

Figure 1

Increased expression of NLRP1 in the neurons of APPswe/PS1dE9 mice brain. (a) Cerebral NLRP1 and NeuN levels from different aged APP/PS1 and wild-type (WT) mice were detected by western blot analysis. β-actin was used as a loading control. (b) Levels of NLRP1, NeuN, and NLRP1/NeuN were quantified by densitometric measurement. Values are the mean±S.E.M. *P<0.05 versus 3-month-old APP/PS1 mice, #P<0.05 versus 6-month-old APP/PS1 mice. (c) Double immunofluorescent detection of NLRP1 in the NeuN-positive neurons of APP/PS1 mice. Tissue samples from 6-month-old APP/PS1 and WT mice were immunostained using anti-NLRP1 and anti-NeuN antibodies and examined under a fluorescence microscope. Scale bars: 20 μm. n=6 male mice per age group

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