Figure 6
From: Amyloid-β induces NLRP1-dependent neuronal pyroptosis in models of Alzheimer’s disease
Schematic model linking the NLRP1 inflammasome activation to AD pathogenesis. High NLRP1 levels were found in pyramidal neurons of the brain. The toxic Aβ peptide can set fire to neuronal NLRP1 inflammasome via potassium efflux. Then, the activation of NLRP1 inflammasome leads to the caspase-1-mediated pyroptosis and secretion of IL-1β, which ultimately induces AD pathology through several downstream effects in brain. Our current study mainly indicated that the caspase-1-induced neuronal pyroptosis provides a molecular basis for cognitive deficits in AD process
