Figure 2 | Cell Death & Disease

Figure 2

From: Compartmentalization of TNF-related apoptosis-inducing ligand (TRAIL) death receptor functions: emerging role of nuclear TRAIL-R2

Figure 2

Nuclear functions of TRAIL-R2. Nuclear TRAIL-R2 interacts with the core Microprocessor complex and its accessory proteins. This inhibits maturation of the let-7 miRNA and results in an increase of the let-7 targets HMGA2 and Lin28B, finally enhancing cell proliferation. The mechanism of the TRAIL-R2 entrance into the nucleus is still not known. The importin-β-mediated transport through nuclear pores or an alternative pathway through Sec61 translocons known to be responsible for the nuclear import of other plasma membrane receptors are possible

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