Figure 3 | Cell Death & Disease

Figure 3

From: Compartmentalization of TNF-related apoptosis-inducing ligand (TRAIL) death receptor functions: emerging role of nuclear TRAIL-R2

Figure 3

Role of nuclear p68, KSRP, hnRNPA1 and NF45/NF90 in pri-let-7-processing. Processing of pri-let-7 by the Microprocessor complex Drosha/DGCR8 is subjected to complex regulation by positive and negative factors. P68, as a more general factor, may function as a scaffolding protein, bringing Drosha and accessory proteins together.106 In addition, p68 can also unwind let-7 miRNA duplex, facilitating the loading of pri-miRNA into Microprocessor complex.105 KSRP binds specifically to the loop region of pri-let-7 promoting Drosha-mediated processing, whereas binding of hnRNPA1 to this region not only prevents the recruitment of KSRP, but also inhibits pri-let-7 processing.107, 108 Similarly, NF45 and NF90, acting mainly as a dimer, can specifically bind to pri-let7 and inhibit its maturation to pre-let-7109

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