Table 1 Intracellular detection of TRAIL death receptors in human tissues

From: Compartmentalization of TNF-related apoptosis-inducing ligand (TRAIL) death receptor functions: emerging role of nuclear TRAIL-R2

Tissue

Cell compartment a

TRAIL-R

Clinical relevance

Reference

Colorectal carcinoma

Cytoplasm

1, 2

TRAIL-R1 is an independent prognostic marker for better prognosis

18,19

Colorectal carcinoma

Cytoplasm

1, 2

Less progressive disease in high expressors of TRAIL-R1 during 5-FU therapy

58

Colon cancer

Cytoplasm

1, 2

ND

64

Breast cancer

Cytoplasm/nucleus

1, 2

TRAIL-R1 expression positively correlates with tumor grade

60

Breast cancer

Cytoplasm

1, 2

High TRAIL-R2 expression correlates with poor prognosis

20,21

Renal carcinoma

Cytoplasm

2

High TRAIL-R2 expression correlates with poor prognosis

61

Non-small-cell lung cancer

Cytoplasm/nucleus

2

High TRAIL-R2 expression correlates with poor prognosis

27

Non-small-cell lung cancer

Cytoplasm

1, 2

High TRAIL-R2 expression correlates with poor prognosis

28

Non-small-cell lung cancer

Cytoplasm/nucleus

2

High expression of nuclear and cytoplasmic TRAIL-R2 correlates with improved patient survival

68

Melanoma

Cytoplasm

1, 2

High TRAIL-R2 expression correlates with better prognosis

62

Pancreatic ductal adenocarcinoma

Cytoplasm

1, 2

Plasma membrane expression of TRAIL-R2 correlates with better prognosis in patients without nodal metastases at the time of surgery

17

Pancreatic ductal adenocarcinoma

Cytoplasm nucleus

2

High nuclear TRAIL-R2 expression correlates with poor prognosis of patients with early stages

16

Glioblastoma multiforme

Cytoplasm

1, 2

High TRAIL-R1 expression correlates with better prognosis

22

Head and neck squamous cell carcinoma

Cytoplasm

2

High TRAIL-R2 expression in primary tumors without metastasis correlates with better prognosis, but high TRAIL-R2 expression in tumors with metastasis correlates with worse prognosis

23

Oral squamous cell carcinoma

Cytoplasm

1, 2

High TRAIL-R2 expression correlates positively with tumor size

26

Cervical cancer

Cytoplasm

1, 2

High expression but no prognostic relevance

24

Bladder cancer

Cytoplasm

1, 2

High TRAIL-R1 and -R2 expression correlates with better prognosis

29

Normal and psoriatic skin lesions

Cytoplasm/nucleus

1, 2

ND

70

CD16+, CD56+ and CD68+ cells in psoriatic skin lesions

Cytoplasm

2

ND

70

CD4+ and CD8+ cells in psoriatic skin lesion

Nucleus

1

ND

70

  1. Abbreviation: ND, not determined
  2. Only intracellular compartments are listed. In many cases, TRAIL death receptors were also observed at the plasma membrane. ‘Cytoplasm’ may comprise all intracellular localizations except the nucleus, as immunohistochemical analyses normally do not discriminate between membranous cytoplasmic compartments and cytosol
Back to article page