Table 2 Intracellular detection of TRAIL death receptors in cultured cell lines and primary cells
Cell line / cells;origin | Cell compartment a | TRAIL-R | Proposed function | Reference |
|---|---|---|---|---|
HCT116; | Cytoplasm | 1 | ND | 16 |
colorectal carcinoma | Nucleus | 1 | ND | |
Cytoplasm | 2 | ND | ||
Nucleus | 2 | Inhibition of let-7 maturation | ||
MDA-MB-231; | Cytoplasm | 1 | ND | 16 |
breast cancer | Nucleus | 1 | ND | |
Cytoplasm | 2 | ND | ||
Nucleus | 2 | Inhibition of let-7 maturation | ||
Panc1, BxPC3, | Cytoplasm | 1 | ND | 16 |
Panc89, Colo357, A818-6; | Nucleus | 1 | ND | |
pancreatic cancer | ||||
Cytoplasm | 2 | ND | ||
Nucleus | 2 | Inhibition of let-7 maturation | ||
AU565, BT474, HCC1428, | Cytoplasm | 1, 2 | Correlation with resistance to TRAIL- | 59 |
MDA-MB-453, MDA-MB-361; breast cancer | Nucleus | mediated apoptosis | ||
BT474, AU565; breast cancer | Autophagosomes | 1, 2 | Resistance to TRAIL-mediated apoptosis | 66 |
Placental primary cytotrophoblast cells | Nucleus | 2 | Correlates with apoptosis resistance | 67 |
Huh-7; hepatocellular carcinoma | Lysosomes | 2 | TRAIL-R2-dependent lysosomal permeabilization promotes apoptosis | 38 |
HepG2; hepatocellular carcinoma | Nucleus | 2 | Resistance to TRAIL-mediated apoptosis | 69 |
HeLa; cervix carcinoma | Nucleus | 2 | Resistance to TRAIL-mediated apoptosis | 69 |
Mel-FH; melanoma | Nucleus | 1 | ND | 65 |
